The XAM-10 mouse manifold enables researchers to anesthetize and image 10 mice at a time, increasing throughput and shortening experiment times. The manifold directs isoflurane gas anesthesia to ten nose cones from a central regulator that allows for easy adjustment of anesthetic delivery. For use only with the IVIS Lumina 5 series and IVIS Spectrum 2 series optical in vivo imaging systems.