Revvity offers a variety of plate seals. TopSeal™ is a range of plate seals that are applied to top surface of plate, and are used to prevent evaporation or radioactive contamination during assay incubation steps and/or plate reading measurements. TopSeal-A can be left on plate during luminescent, AlphaScreen®, AlphaLISA™, and radiometric measurements. TopSeal plate seals have spectral properties that may interfere with or types of assay measurements (absorbance assays, colorimetric assays, fluorescence assays). se types of assays, you should compare plate measurement with and without a TopSeal plate seal to test interference.