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NanoAssemblr™ Blaze nanoparticle formulation system

Supplied by Cytiva

$131,650.00/EA

Average lead time:
Call for Lead Time

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Product Description

Specifications

Additional Information

Product Description

NanoAssemblr™ Blaze+™ System Upgrade

Specifications

Inventory Number:

GEHNIB0061EA

Part Number:

NIB0061

Supplier:

Cytiva

Supplier's Lead Time:

Call for Lead Time

Quantity:

1 per EA

Contract Availability:

GSA

Country of Origin:

Canada

Features and Benefits 1::

Efficient: Validate end-to-end clinical manufacturing processes, including tangential flow filtration (TFF), sterile filtration, and fill/finish operations on a preclinical system with a simplified setup and shorter run times, saving time and resources.

Features and Benefits 2::

Flexible volume options: Select the Blaze system for low-volume applications (up to 1 L) or upgrade to the Blaze+ system for high-volume applications (up to 10 L), enabling toxicity, stability, and large-cohort in vivo animal studies.

Features and Benefits 3::

Closed system environment: The Blaze+ system provides a closed system environment that enables external vessel connections and includes a software upgrade, reducing the risk of contamination during scale-up.

Features and Benefits 4::

Scalable: Easily transfer critical process parameters (CPPs) to the NanoAssemblr™ commercial formulation system, enabling smooth technology transfer to a cGMP facility.

Features and Benefits 5::

Reproducible: NxGen™ technology ensures consistent, controlled mixing conditions, enabling reproducible, robust particle formation.

Overview:

The NanoAssemblr™ Blaze and Blaze+ systems streamline the process development of lipid nanoparticle (LNP) formulation, enabling the efficient scaling from early research through preclinical and early clinical development. With flexible volume options and a closed system environment, these systems support early chemistry, manufacturing, and control (CMC) studies and large-scale protocol development for upstream and downstream operations, providing valuable insights into processes and consumables required for GMP manufacturing.

Overview 2:

NxGen™ cartridges and tubing kits Single-use NxGen™ cartridges reduce the risk of cross-contamination and are available with or without in-line dilution, which automates a key process and streamlines the LNP workflow. The cartridges use the same mixer as the NanoAssemblr™ Ignite+ and NanoAssemblr™ commercial formulation system, enabling the direct transfer of CPPs from bench to process development and clinical and commercial production.

Overview 3:

The single-use tubing kit enables external vessel connections and a closed-system environment for the Blaze+ system.

Overview 4:

Starting June 2025, customers can purchase the new NxGen™ Blaze cartridges for the NanoAssemblr™ Blaze nanoparticle formulation system and will have the option to reuse them. Blaze system NxGen™ cartridges remain validated for single use only, up to 1 L on the Blaze system or 10 L on the Blaze+ system. Further information can be found in the Blaze user guide.

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NanoAssemblr™ Blaze nanoparticle formulation system

Supplied by Cytiva

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