MabSelect™ antibody purification chromatography resin, 25 mL
Highflow agarose matrix allows for high flow velocities at production scale enabling the processing of more than 1NA NANANA L of feed in one working day.
Oriented coupling of the ligand and optimized matrix gives high dynamic binding capacity which reduces media volume requirements
Low nonspecific binding resulting in low levels of impurities in the product eluate pool
BioProcess medium supported for industrial applications and wellestablished in approved processes.
MabSelect is a BioProcess affinity medium for capturing monoclonal antibodies (MAbs) from large sample volumes. MabSelect is developed for costeffective high throughput processing of large amounts of feed. This is the reason why MabSelect has been designedin to several new and secondgeneration processes for the production of therapeutic MAbs.
The medium is based on a highly crosslinked agarose matrix with a recombinant protein A ligand. This ligand is engineered to favor an oriented coupling resulting in an affinity medium with enhanced binding capacity for IgG. The hydrophilic nature of the base matrix ensures low levels of nonspecific binding leading to low levels of host cellderived impurities in the elution pool. MabSelect is optimized for high capacity, throughput and to deliver a product pool that is high in purity and yield.
The recombinant Protein A ligand is expressed in E. coli and is free of components of mammalian origin. The specificity of binding to the Fc region of IgG is similar to that of native protein A giving a high purification factor in a single step. In addition, the high capacity and the novel base matrix make MabSelect an excellent choice for purification of MAbs at process scale MabSelect is available in a range of different bulk pack sizes and convenient prepacked formats for easy scaleup and process development.
As member of the BioProcess media range, MabSelect meets industrial demands with security of supply and comprehensive technical and regulatory support.