MabSelect SuRe LX protein A resin, 25 mL
Novel, alkalitolerant rProtein A ligand withstands rigorous CIP and sanitization procedures with NA.1 to NA.5 M NaOH.
High dynamic binding capacity (DBC) for high titer cultures reduces process time and amount of resin used.
Fulfills industrial demands for security of supply, robust performance, and regulatory support.
MabSelect SuRe LX is a member of the MabSelect family of affinity chromatography media for the capture of monoclonal antibodies (MAbs) at process scale. MabSelect SuRe LX shares features and benefits of MabSelect and MabSelect SuRe such as a rigid, highflow agarose matrix that ensures excellent pressure/flow properties, low nonspecific binding that leads to low impurity levels in the eluate pool, and an oriented ligand coupling for optimal binding capacity. It also features the same alkalitolerant rProtein A ligand as MabSelect SuRe. This ligand provides greater stability than conventional protein Abased media in the alkaline conditions used in cleaninginplace (CIP) and sanitization protocols. The enhanced alkali stability of MabSelect SuRe improves process economy and product quality; cleaning can be performed with costeffective reagents such as sodium hydroxide eliminating the need for expensive and hazardous cleaning agents such as GuaHCl. Process economy is also improved by the increased dynamic binding capacity of MabSelect SuRe LX.
Just as for MabSelect SuRe, the novel ligand construct of MabSelect SuRe LX has been proven to have an increased stability towards proteases. Therefore, the level of leakage of the MabSelect SuRe LX ligand during elution is low.
MabSelect SuRe has been demonstrated to give generic elution conditions for different monoclonal antibodies which can be applied also to MabSelect SURe LX since it utilizes the same ligand. This is an advantage when designing generic purification platform processes. The feature is also correlated to the construction of the MabSelect SuRe ligand MabSelect SuRe LX is available in a range of different bulk pack sizes and convenient prepacked formats for easy scaleup and process development.
As member of the BioProcess media range, MabSelect SuRe meets industrial demands with security of supply and comprehensive technical and regulatory support.