MabSelect SuRe antibody purification resin, 200 mL
Novel, alkalitolerant rProtein A ligand withstands rigorous CIP and sanitization procedures with NA.1 to NA.5 M NaOH.
Reduces the risk of product contamination and carryover
Improves product quality and reduces overall costs
Novel ligand design gives enhanced protease resistance resulting in lower ligand leakage
Generic elution profile for different monoclonal antibodies enables platform approach to purification
Used in the commercial manufacture of monoclonal antibodies
Highflow agarose matrix allows the processing of large feed volumes
MabSelect SuRe is a member of the MabSelect family of affinity chromatography media for the capture of monoclonal antibodies (MAbs) at process scale. MabSelect SuRe shares features and benefits of MabSelect such as a rigid, highflow agarose matrix that ensures excellent pressure/flow properties, low nonspecific binding that leads to low impurity levels in the eluate pool, and an oriented ligand coupling for optimal binding capacity. In addition, MabSelect SuRe features an alkalitolerant rProtein A ligand. This ligand provides greater stability than conventional protein Abased media in the alkaline conditions used in cleaninginplace (CIP) and sanitization protocols. The enhanced alkali stability of MabSelect SuRe improves process economy and product quality; cleaning can be performed with costeffective reagents such as sodium hydroxide eliminating the need for expensive and hazardous cleaning agents such as GuaHCl.
The novel ligand construct of MabSelect SuRe has been proven to have an increased stability towards proteases. Therefore, the level of leakage of the MabSelect SuRe ligand during elution is low.
MabSelect SuRe has been demonstrated to give generic elution conditions for different monoclonal antibodies, which is an advantage when designing generic purification platform processes. This feature is also correlated to the construction of the MabSelect SuRe ligand MabSelect SuRe is available in a range of different bulk pack sizes and convenient prepacked formats for easy scaleup and process development. As member of the BioProcess media range, MabSelect SuRe meets industrial demands with security of supply and comprehensive technical and regulatory support. The improved process economy derived from MabSelect SuRe as a component in the production of therapeutic MAbs has led to the http://www.gelifesciences.com/webapp/wcs/stores/servlet/catalog/GELifeSciences/brands/mabselectsurevalidation of MabSelect SuRe as a healthymagination innovation.